Использование результатов однофотонной эмиссионной компьютерной томографии с [99mТс]-МИБИ на этапах предоперационной терапии у больных раком молочной железы

Aim. Study of the possibilities using quantitative parameters single-photon emission computed tomography (SPECT) with [99mTс]-MIBI as predictors effectiveness neoadjuvant chemotherapy (NAC) in patients breast cancer (BC). Materials and methods. The study included 47 ВС T1-4N0-3M0 stages. SPECT was performed before after 2nd course NAC, a scintigraphic 20 minutes 2 hours administration calculation tumor/background accumulation coefficient (TB) retention index (IR). Results. When comparing between groups stabilization, partial regression tumor complete regression, no statistically significant relationships were noted. Subsequently, divided into response to therapy an objective (partial regression). IR demonstrated difference these - lower indicator observed treatment. ROC-analysis used assess threshold values ​​in predicting therapy, which demonstrates that is predictor moderate strength and, at value less than 0.175, predicts NAC sensitivity 75% specificity 60%. Conclusion. use [99mTc]-MIBI stages preoperative treatment can provide not only quick assessment response, but also be early resistance. Retention ​​less 0.175 predict